Synuclein-α Monoclonal Antibody

    • Catalog No.：YM0606
    • Applications：WB;IHC;IF;ELISA
    • Reactivity：Human
      • Target：
      • Synuclein-α
      • Fields：
      • >>Alzheimer disease;>>Parkinson disease;>>Pathways of neurodegeneration - multiple diseases
      • Gene Name：
      • SNCA
      • Protein Name：
      • Alpha-synuclein
      • Human Gene Id：
      • 6622
      • Human Swiss Prot No：
      • P37840
      • Mouse Swiss Prot No：
      • O55042
      • Immunogen：
      • Purified recombinant fragment of Synuclein-α expressed in E. Coli.
      • Specificity：
      • Synuclein-α Monoclonal Antibody detects endogenous levels of Synuclein-α protein.
      • Formulation：
      • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
      • Source：
      • Monoclonal, Mouse
      • Dilution：
      • WB 1:500 - 1:2000. IHC 1:200 - 1:1000. ELISA: 1:10000.. IF 1:50-200
      • Purification：
      • Affinity purification
      • Storage Stability：
      • -15°C to -25°C/1 year(Do not lower than -25°C)
      • Other Name：
      • SNCA;NACP;PARK1;Alpha-synuclein;Non-A beta component of AD amyloid;Non-A4 component of amyloid precursor;NACP
      • Molecular Weight(Da)：
      • 14kD
      • References：
      • 1. J. Johnson, S. M. Hague, M. Hanson. Neurology, Aug 2004; 63: 554 – 556
        2. Hong Tao Li, Xiao Jing Lin, Yuan Yuan Xie. Protein Pept Lett. 2006;13(4):385-90.
      • Background：
      • Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2016],
      • Function：
      • alternative products:Additional isoforms seem to exist,disease:Brain iron accumulation type 1 (NBIA1, also called Hallervorden-Spatz syndrome), a rare neuroaxonal dystrophy, is histologically characterized by axonal spheroids, iron deposition, Lewy body (LB)-like intraneuronal inclusions, glial inclusions and neurofibrillary tangles. SNCA is found in LB-like inclusions, glial inclusions and spheroids.,disease:Defects in SNCA are a cause of autosomal dominant Parkinson disease 1 (PARK1) [MIM:168601, 168600]. Parkinson disease (PD) is a complex, multifactorial disorder that typically manifests after the age of 50 years, although early-onset cases (before 50 years) are known. PD generally arises as a sporadic condition but is occasionally inherited as a simple mendelian trait. Although sporadic and familial PD are very similar, inherited forms of the disease usually begin at earlier ages an
      • Subcellular Location：
      • Cytoplasm . Membrane . Nucleus . Cell junction, synapse . Secreted . Cell projection, axon . Membrane-bound in dopaminergic neurons (PubMed:15282274). Expressed and colocalized with SEPTIN4 in dopaminergic axon terminals, especially at the varicosities (By similarity). .
      • Expression：
      • Highly expressed in presynaptic terminals in the central nervous system. Expressed principally in brain.
      • Products Images
      • Western Blot analysis using Synuclein-α Monoclonal Antibody against truncated Synuclein-α recombinant protein.
      • Immunohistochemistry analysis of paraffin-embedded human glioma tissue, showing membrane localization with DAB staining using Synuclein-α Monoclonal Antibody.

      Attributes

      • Code：
      • YM0606
      • Size
      • 50μL / 100μL / 200μL
      • Price$：
      • 210 / 350 / 600
      • Delivery：
      • 2024-05-09
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