• 靶点：
• Tubulin α

• 简介：
• >>Phagosome;>>Apoptosis;>>Tight junction;>>Gap junction;>>Alzheimer disease;>>Parkinson disease;>>Amyotrophic lateral sclerosis;>>Huntington disease;>>Prion disease;>>Pathways of neurodegeneration - multiple diseases;>>Pathogenic Escherichia coli infection;>>Salmonella infection

• 基因名称：
• TUBA1A

• 蛋白名称：
• Tubulin alpha-1A chain

• Human Gene Id：
• 7846/10376

• Human Swiss Prot No：
• Q71U36/P68363

• Mouse Gene Id：
• 22142/22143

• Rat Gene Id：
• 64158/500929

• Rat Swiss Prot No：
• P68370/Q6P9V9

• 免疫原：
• Recombinant Protein of Tubulin alpha-1A chain. AA range: 350-451

• 特异性：
• The antibody detects endogenousα-tubulin protein.

• 组成：
• PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.

• 来源：
• Monoclonal, Mouse,IgG2b, Kappa

• 稀释：
• WB 1:500-10000,IHC 1:50-300

• 纯化工艺：
• The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 分子量：
• 50kDa

• 实测条带：
• 50kD

• 背景：
• Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulins. The genes encoding these microtubule constituents belong to the tubulin superfamily, which is composed of six distinct families. Genes from the alpha, beta and gamma tubulin families are found in all eukaryotes. The alpha and beta tubulins represent the major components of microtubules, while gamma tubulin plays a critical role in the nucleation of microtubule assembly. There are multiple alpha and beta tubulin genes, which are highly conserved among species. This gene encodes alpha tubulin and is highly similar to the mouse and rat Tuba1 genes. Northern blotting studies have shown that the gene expression is predominantly found in morphologically differentiated neurologic cells. This gene is one of three alpha-tubulin genes in a cluster on chromosome 12q.

• 功能：
• disease:Defects in TUBA1A are the cause of lissencephaly type 3 (LIS3) [MIM:611603]. LIS is characterized by a smooth brain surface due to the absence (agyria) or reduction (pachygyria) of surface convolutions. It is often associated with psychomotor retardation and seizures. LIS3 features include agyria or pachygyria or laminar heterotopia, severe mental retardation, motor delay, variable presence of seizures, and abnormalities of corpus callosum, hippocampus, cerebellar vermis and brainstem.,function:Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain.,PTM:Undergoes a tyrosination/detyrosination cycle, the cyclic removal and re-addition of a C-terminal tyrosine residue by the enzymes tubulin tyrosine carboxypeptidase (TTCP) and tubulin tyrosine ligase (TTL), resp

• 细胞定位：
• Cytoplasm, cytoskeleton.

• 组织表达：
• Expressed at a high level in fetal brain.

Sulforaphane downregulated fatty acid synthase and inhibited microtubule-mediated mitophagy leading to apoptosis. Cell Death & Disease Cell Death Dis. 2021 Oct;12(10):1-13 Co-IP,WB Human A549 cell,SK-1 cell
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LIGHT (TNFSF14) inhibits glucose uptake of adipocytes by downregulating GLUT4 expression via AKT signaling pathway. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS Biochem Bioph Res Co. 2021 Dec;583:106 WB Mouse Adipose tissue Murine 3T3-L1 preadipocytes
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APPL1 Is a Prognostic Biomarker and Correlated with Treg Cell Infiltration via Oxygen-Consuming Metabolism in Renal Clear Cell Carcinoma Oxidative Medicine and Cellular Longevity Hengyi Xiao WB Mouse HK-2 cell,768O cell,769P cell,Caki-1 cell
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Reducing GEF-H1 Expression Inhibits Renal Cyst Formation, Inflammation, and Fibrosis via RhoA Signaling in Nephronophthisis INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Liangzhong Sun
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Cross-Ethnic Variant Screening and Burden Analysis of PTPA in Parkinson's Disease MOVEMENT DISORDERS Huifang Shang WB Human HEK293 cell
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Nutritional Programming of the Lifespan of Male Drosophila by Activating FOXO on Larval Low-Nutrient Diet Nutrients Mingyao Yang WB Fruit fly body
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Vagus nerve stimulation-induced stromal cell-derived factor-l alpha participates in angiogenesis and repair of infarcted hearts. ESC Heart Failure Jun-ming Tang WB Human 1:500 human coronary endothelial cells
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