RBBP5 mouse mAb

    • Catalog No.：YM1445
    • Applications：WB;IF
    • Reactivity：Human;Mouse;Rat
      • Target：
      • RBBP5
      • Fields：
      • >>Cushing syndrome
      • Gene Name：
      • rbbp5
      • Human Gene Id：
      • 5929
      • Human Swiss Prot No：
      • Q15291
      • Mouse Swiss Prot No：
      • Q8BX09
      • Immunogen：
      • Purified recombinant human RBBP5 protein fragments expressed in E.coli.
      • Specificity：
      • This antibody detects endogenous levels of RBBP5 and does not cross-react with related proteins.
      • Formulation：
      • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
      • Source：
      • Monoclonal, Mouse
      • Dilution：
      • wb dilution 1:1000 icc dilution 1:100. IF 1:50-200
      • Purification：
      • The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
      • Concentration：
      • 1 mg/ml
      • Storage Stability：
      • -15°C to -25°C/1 year(Do not lower than -25°C)
      • Other Name：
      • RBBP 5;RBBP-5;RBBP5;RBBP5_HUMAN;RBQ 3;RBQ3;Retinoblastoma binding protein 5;Retinoblastoma binding protein RBQ3;Retinoblastoma binding protein5;Retinoblastoma-binding protein 5;Retinoblastoma-binding protein RBQ-3;SWD1;SWD1, Set1c WD40 repeat protein, homolog.
      • Observed Band(KD)：
      • 70kD
      • Background：
      • This gene encodes a ubiquitously expressed nuclear protein which belongs to a highly conserved subfamily of WD-repeat proteins. The encoded protein binds directly to retinoblastoma protein, which regulates cell proliferation. It interacts preferentially with the underphosphorylated retinoblastoma protein via the E1A-binding pocket B. Three alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2010],
      • Function：
      • function:Binds preferentially to underphosphorylated retinoblastoma protein.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 6 WD repeats.,subunit:Component of the SET1 complex, at least composed of the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2/ASH2L and CXXC1/CFP1. Component of MLL-containing complexes (named MLL, ASCOM, MLL2/MLL3 or MLL3/MLL4 complex): at least composed ASH2L, RBBP5, DPY30, WDR5, one or several histone methyltransferases (MLL, MLL2, MLL3 and/or MLL4), and the facultative components MEN1, HCFC1, HCFC2, NCOA6, KDM6A, PAXIP1/PTIP and C16orf53/PA1.,tissue specificity:Ubiquitously expressed.,
      • Subcellular Location：
      • Nucleus .
      • Expression：
      • Ubiquitously expressed.
      • Products Images
      • Western blot detection of RBBP5 in C2C12,THP-1,PC12 and 3T3 cell lysates using RBBP5 mouse mAb (1:1000 diluted).Predicted band size:70KDa.Observed band size:70KDa.
      • Immunofluorescent analysis of Hela cells fixed with 4% Paraformaldehyde and using anti-RBBP5 mouse mAb (dilution 1:100). DAPI was used to stain nucleus(blue).

      Attributes

      • Code：
      • YM1445
      • Size
      • 40μL / 100μL / 200μL
      • Price$：
      • 160 / 280 / 450
      • Delivery：
      • 2024-05-06
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